Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56658   TFG_HUMAN
MINT-73504   EPOR_HUMAN
MINT-74919   FCG2B_HUMAN
MINT-6761906   ESR1_HUMAN
MINT-6793815   CAV1_HUMAN
MINT-6799844   ROS_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 cytosol,
nucleus,
membrane		 apoptosis,
protein amino acid dephosphorylation,
signal transduction,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 536 LQSQKGQESEYGNITYPPAMK - 12468540
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK Lck 8114715
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK Abl 8692915
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 7512963
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 14757045
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK SRC 14699166
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 18083107
HTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE - 12468540
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 8114715
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE Abl 8692915
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE - 14757045
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE SRC 14699166
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 10488096
LTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
Y 564 RTSSKHKEDVYENLHTKNKRE - 18083107
HTP
0.31
 PIK3R1 SH2;
SH3BP2 SH2		 -
0.72
 - low
S 591 RSADKEKSKGSLKRK       PKC_alpha 15269224
LTP
1.00
 - -
0.78
 - low

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29351 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-74896   EPOR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein tyrosine phosphatase activity,
phosphotyrosine binding,
SH2 domain binding		 cytoplasm,
nucleus,
alpha-beta T cell receptor complex		 intracellular signaling pathway,
B cell receptor signaling pathway,
negative regulation of T cell proliferation,
negative regulation of MAP kinase activity,
cytokine-mediated signaling pathway,
natural killer cell mediated cytotoxicity,
negative regulation of T cell receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
protein amino acid dephosphorylation,
negative regulation of humoral immune response mediated by circulating immunoglobulin,
negative regulation of MAPKKK cascade,
regulation of B cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 536 IQSQKGQESEYGNITYPPAVR - 8114715
LTP
1.00
 - -
0.52
 - medium
Y 564 RTSSKHKEEVYENVHSKSKKE - 8114715
LTP
1.00
 - -
0.68
 - medium

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29351-3 [Mus musculus]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein tyrosine phosphatase activity,
phosphotyrosine binding,
SH2 domain binding		 cytoplasm,
nucleus,
alpha-beta T cell receptor complex		 intracellular signaling pathway,
B cell receptor signaling pathway,
negative regulation of T cell proliferation,
negative regulation of MAP kinase activity,
cytokine-mediated signaling pathway,
natural killer cell mediated cytotoxicity,
negative regulation of T cell receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
protein amino acid dephosphorylation,
negative regulation of humoral immune response mediated by circulating immunoglobulin,
negative regulation of MAPKKK cascade,
regulation of B cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 497 IQSQKGQESEYGNITYPPAVR - 19144319
HTP
1.00
 - -
0.52
 - medium

Valid HTML 4.01 Transitional